Tripartite motif proteins: an emerging antiviral protein family
نویسندگان
چکیده
منابع مشابه
Tripartite Motif Proteins - A Protein Family Strongly Linked to Cancer
Cancer is a highly prevalent genetic disease and it is estimated that almost every second person will suffer from the disease during his or her life-time. Despite intensive research over the last 50 years, the development and progression of the disease is, in many cases, still incompletely understood. In the past few years, a distinctive family of proteins called the TRIM (tripartite motif), or...
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The innate immune system recognizes microbial components through pattern-recognition receptors (PRRs), including membrane-bound Toll-like receptors and cytosolic receptors such as RIG-I-like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense...
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BACKGROUND The tripartite motif family protein 27 (TRIM27) is a transcriptional repressor that interacts with, and attenuates senescence induction by, the retinoblastoma-associated protein (RB1). High expression of TRIM27 was noted in several human cancer types including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis. Here, we investigated the role of TR...
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The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5alpha and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles. Here, we describe how the C-terminal PRYSPRY domain mediates diverse TRIM functions. The crystal structure of TRIM21 PRYSPRY in complex with its target Ig...
متن کاملTRIM 37 ( tripartite motif - containing 37 )
Hugo: TRIM37 Other names: MUL; KIAA0898; POB1; TEF3 Location: 17q23.2 Local order: Genes flanking TRIM37 oriented from centromere to telomere on 17q23 are: RAD51C, 17q22-q23, D51 homolog C (S. Cerevisiae) PPM1E, 17q23.2, protein phosphatase 1E (PP2C domain containing) TRIM37, 17q22-q23, tripartite motif-containing 37 FAM33A 17q23.2, family with sequence similarity 33, member A PRR11(FLJ11029) 1...
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ژورنال
عنوان ژورنال: Future Virology
سال: 2019
ISSN: 1746-0794,1746-0808
DOI: 10.2217/fvl-2018-0161